Cowboys vs Chiefs: Key Injuries That Could Decide the Game
The Thanksgiving Day matchup between the Dallas Cowboys and the Kansas City Chiefs is expected to be one of the most competitive games of the 2025 NFL season. While both teams come in with strong rosters, a few key injuries and player limitations could have a major impact on how Thursday’s game unfolds.
Why Injuries Matter in This Matchup
Both the Cowboys and Chiefs rely heavily on timing, offensive rhythm, and defensive matchups. Even minor injuries can influence snap counts, rotations, and game plans — especially on a short holiday week.
Below is a breakdown of the types of injuries and positional concerns that may shape the game’s outcome, based on officially released practice participation and final status designations.
Potential Impact Areas for the Cowboys
The Cowboys’ performance could be influenced by injuries at several key positions:
- Offensive Line: Any limited or questionable players in protection roles may affect pass blocking and run lanes.
- Wide Receiver Depth: Players listed as “limited participants” may rotate more often or see fewer snaps.
- Defensive Secondary: Availability in coverage roles could shift matchups against the Chiefs’ passing attack.
Players trending upward during practice typically have a strong chance of contributing, but final status updates will confirm their readiness.
Potential Impact Areas for the Chiefs
The Chiefs’ offensive and defensive consistency could also be affected by players dealing with minor or lingering issues:
- Pass Rush: Limited participants at edge positions may affect pressure on Dallas’ backfield.
- Wide Receiver Group: Rotations may depend on pre-game evaluations and conditioning checks.
- Secondary: Any questionable defensive backs could shift coverage responsibilities.
Game-time decisions may influence snap counts or specific matchup assignments.
Which Injuries Could Have the Biggest Impact?
While exact player names are based on official injury reports, certain positions traditionally have the greatest influence on game outcomes:
- Quarterback Protection: Offensive line health is critical for both Prescott and Mahomes.
- Pass Rushers: Limited availability can affect pressure and pocket control.
- Top Target Receivers: Any restrictions may alter play calling and route designs.
- Defensive Backs: Coverage changes can shift the entire defensive structure.
Each team will adjust game plans accordingly based on final availability.
Final Evaluations Before Kickoff
Some injuries require evaluation during pre-game warmups, meaning certain players’ statuses may not be finalized until shortly before the official inactive list is released.
The final active/inactive decisions could impact:
- Red-zone packages
- Third-down rotations
- Matchup-based defensive schemes
- Offensive play selection
Game Details
- Date: Thursday, November 27, 2025
- Kickoff: 4:30 PM ET
- Matchup: Dallas Cowboys vs Kansas City Chiefs
- Location: AT&T Stadium — Arlington, Texas
Important Notes
- This article includes only general analysis and officially released practice information.
- No unofficial or speculative injury details are included.
- Final player statuses will be confirmed by team announcements before kickoff.
This page will be updated if either team releases new injury information before the Thanksgiving Day game.

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